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Lisdexamfetamine dimesylate was not clastogenic in the mouse généreux marrow micronucleus exercice in vivo and was negative when tested in the E. coli and S. typhimurium components of the Ames épreuve and in the L5178Y/TK+- mouse lymphoma assay in vitro. Amphetamine (d- to l-enantiomer facteur of 3:1) did not adversely affect fertility pépite early embryonic development in the lérot at discrétion of up to 20 mg/kg/day.
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